Segmented diffusion imaging with iterative motion-corrected reconstruction (SEDIMENT) for brain echo-planar imaging.

Multi-shot techniques offer improved resolution and signal-to-noise ratio for diffusion- weighted imaging, but make the acquisition vulnerable to shot-specific phase variations and inter-shot macroscopic motion. Several model-based reconstruction approaches with iterative phase correction have been proposed, but robust macroscopic motion estimation is still challenging. Segmented diffusion imaging with iterative motion-corrected reconstruction (SEDIMENT) uses iteratively refined data-driven shot navigators based on sensitivity encoding to cure phase and rigid in-plane motion artifacts. The iterative scheme is compared in simulations and in vivo with a non-iterative reference algorithm for echo-planar imaging with up to sixfold segmentation. The SEDIMENT framework supports partial Fourier acquisitions and furthermore includes options for data rejection and learning-based modules to improve robustness and convergence.