Login / Signup

Chemical Biology of Protein N-Terminal Methyltransferases.

Rong Huang
Published in: Chembiochem : a European journal of chemical biology (2019)
Protein α-N-terminal methylation is catalyzed by protein N-terminal methyltransferases. The prevalent occurrence of this methylation in ribosomes, myosin, and histones implies its function in protein-protein interactions. Although its full spectrum of function has not yet been outlined, recent discoveries have revealed the emerging roles of α-N-terminal methylation in protein-chromatin interactions, DNA damage repair, and chromosome segregation. Herein, an overview of the discovery of protein N-terminal methyltransferases and functions of α-N-terminal methylation is presented. In addition, substrate recognition, mechanisms, and inhibition of N-terminal methyltransferases are reviewed. Opportunities and gaps in protein α-N-terminal methylation are also discussed.
Keyphrases
  • dna damage
  • genome wide
  • protein protein
  • dna methylation
  • binding protein
  • amino acid
  • small molecule
  • high throughput
  • single cell
  • copy number
  • room temperature