Retrospective validation of a rapid Lyme fluorescent immunoassay in differentiating Lyme arthritis from other musculoskeletal presentations in children in a Lyme-endemic region.
Alexis DonovanRebecca QuiltyBryn K JoyShahriar SeddighHeather CoatsworthLuke GauthierJeannette L ComeauBianca LangJason LeblancTodd HatchetteElizabeth StringerPublished in: Microbiology spectrum (2024)
Lyme arthritis is a common manifestation of Lyme disease in children, with clinical features overlapping with other causes of acute and chronic joint pain/swelling in children. We have demonstrated that the Sofia IgG is a reliable test to rule in and rule out the diagnosis of Lyme arthritis in children with musculoskeletal presentations in a Lyme-endemic region. When used in conjunction with clinical and laboratory variables routinely considered when differentiating Lyme arthritis from other diagnoses, the Sofia IgG has the potential to fill an important gap in care, especially when acute decision-making is necessary. The Sofia IgG should be included in prospective research studies examining clinical prediction tools to identify children at low risk of septic arthritis.
Keyphrases
- rheumatoid arthritis
- young adults
- healthcare
- decision making
- acute kidney injury
- palliative care
- magnetic resonance imaging
- intensive care unit
- magnetic resonance
- chronic pain
- drug induced
- spinal cord
- quality improvement
- acute respiratory distress syndrome
- sensitive detection
- aortic dissection
- single molecule
- case control