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Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?

Xinkun ChengTorsten LowinNadine HonkeGeorg Pongratz
Published in: Journal of inflammation (London, England) (2023)
RASFs possess a complete and functional catecholamine machinery whose function is altered under inflammatory conditions. Results from this study shed further light on the involvement of sympathetic neurotransmitters in RA pathology and might open therapeutic avenues to counteract inflammation with the MAO enzymes being key candidates.
Keyphrases
  • rheumatoid arthritis
  • oxidative stress
  • disease activity
  • ankylosing spondylitis
  • interstitial lung disease
  • systemic lupus erythematosus
  • extracellular matrix
  • idiopathic pulmonary fibrosis
  • systemic sclerosis