Bioequivalence study followed by model-informed dose optimization of a powder for oral suspension of 6-mercaptopurine.
Bhavatharini ArunMahendra JoshiArchana Khosa KakkarShivkumar MadkiVijay IvaturiGirish ChinnaswamyShripad BanavaliVikram GotaPublished in: Pediatric blood & cancer (2023)
6MP PFOS 10 mg/mL should be administered at a 20% lower dose than the tablet to achieve comparable exposure. 6MP PFOS addresses an unmet medical need for a liquid formulation of 6MP in the Indian subcontinent.
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