Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression.

Wiesje Pelkmans Mahnaz Shekari Anna Brugulat-Serrat Gonzalo Sánchez-Benavides Carolina Minguillón Karine Fauria José Luis L Molinuevo Oriol Grau-RiveraArmand González EscalanteGwendlyn KollmorgenMargherita Carboni Nicholas James Ashton Henrik ZetterbergKaj BlennowMarc Suarez-Calvet Juan-Domingo Gispertnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

was directly linked to higher plasma GFAP concentrations. Plasma GFAP partially explained the relationship between soluble Aβ and insoluble Aβ. CSF YKL-40 mediated Aβ-induced tau phosphorylation and tau-induced neuronal injury.

Keyphrases

high glucose
diabetic rats
cerebrospinal fluid
drug induced
cognitive decline
oxidative stress
endothelial cells
protein kinase
blood brain barrier
mild cognitive impairment