1,2,3-Triazole Bridge as Conformational Constrain in β-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions.
V CelentanoD DianaC Di SalvoL De RosaA RomanelliR FattorussoLuca Domenico D'AndreaPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
Conformational constrained β-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the β-hairpin peptide. The entity of the stability of the β-hairpin peptide depends on the length of the bridge.