Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer's Disease Patients.
Stella GagliardiMarta TruffiVeronica TinelliMaria GarofaloCecilia PandiniMatteo Cotta RamusinoGiulia PeriniAlfredo CostaSara NegriSerena MazzucchelliArianna BonizziLeopoldo SitiaMaria BusaccaMarta SevieriMichela MocchiAlessandra RicciardiDavide ProsperiFabio CorsiCristina CeredaCristina CeredaPublished in: International journal of molecular sciences (2022)
Our data showed how BDC-Hfn could improve the stability of BDC. Significant differences in genes associated with inflammation between the same patients before and after BDC-Hfn treatment have been found. Inflammatory genes that are upregulated between AD and CTR after BDC-HFn treatment are converted and downregulated, suggesting a possible therapeutic approach.