Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.

Csilla SipekyPing GaoQin ZhangLiang Wang Otto O EttalaKirsi M TalalaTeuvo L J TammelaAnssi Auvinen Fredrik WiklundGong-Hong WeiJohanna Schleutker

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Simultaneous presence of HOXB13 T and CIP2A T alleles confers for high prostate cancer risk and aggressiveness of disease, earlier biochemical relapse, and lower disease-specific life expectancy. HOXB13 protein binds to CIP2A gene and functionally promotes CIP2A transcription.

Keyphrases

prostate cancer
radical prostatectomy
genome wide
transcription factor
copy number
gene expression
small molecule
cancer therapy
protein protein
binding protein