TGF-β1 regulates the lncRNA transcriptome of ovarian granulosa cells in a transcription activity-dependent manner.
Qiqi LiYangan HuoSiqi WangLiu YangQifa LiXing DuPublished in: Cell proliferation (2022)
Our findings demonstrate that TGF-β1 alters lncRNA transcriptome in a SMAD4-dependent manner, and highlight that lncRNAs mediate the functions of TGF-β1 in GCs, which contribute to a better understanding of the epigenetic regulation of female fertility.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- rna seq
- induced apoptosis
- single cell
- gene expression
- long non coding rna
- genome wide
- cell cycle arrest
- transcription factor
- type diabetes
- polycystic ovary syndrome
- endoplasmic reticulum stress
- metabolic syndrome
- adipose tissue
- skeletal muscle
- childhood cancer