Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium.
Douglas J HarrisonJonathan D GillMichael E RothWendong ZhangBeverly TeicherStephen EricksonGreg GattoRaushan T KurmashevaPeter J HoughtonMalcolm A SmithEdward Anders KolbRichard GorlickPublished in: Pediatric blood & cancer (2020)
The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.