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Protective Roles of Hydrogen Sulfide in Alzheimer's Disease and Traumatic Brain Injury.

Bindu D PaulAndrew A Pieper
Published in: Antioxidants (Basel, Switzerland) (2023)
The gaseous signaling molecule hydrogen sulfide (H 2 S) critically modulates a plethora of physiological processes across evolutionary boundaries. These include responses to stress and other neuromodulatory effects that are typically dysregulated in aging, disease, and injury. H 2 S has a particularly prominent role in modulating neuronal health and survival under both normal and pathologic conditions. Although toxic and even fatal at very high concentrations, emerging evidence has also revealed a pronounced neuroprotective role for lower doses of endogenously generated or exogenously administered H 2 S. Unlike traditional neurotransmitters, H 2 S is a gas and, therefore, is unable to be stored in vesicles for targeted delivery. Instead, it exerts its physiologic effects through the persulfidation/sulfhydration of target proteins on reactive cysteine residues. Here, we review the latest discoveries on the neuroprotective roles of H 2 S in Alzheimer's disease (AD) and traumatic brain injury, which is one the greatest risk factors for AD.
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