PCNA-associated factor (KIAA0101/PCLAF) overexpression and gene copy number alterations in hepatocellular carcinoma tissues.
Anchalee TantiwetrueangdetRavat PanvichienPattana SornmayuraSurasak LeelaudomlipiJill A MacoskaPublished in: BMC cancer (2021)
KIAA0101/PCLAF mRNA and protein overexpression is frequently observed in HCC but without concurrent KIAA0101/PCLAF gene amplification. Significant correlations between the expression of KIAA0101 protein and p53 and Ki-67 proteins were observed in this study. Thus, detection of KIAA0101/PCLAF mRNA/protein might be used, along with the detection of p53 and Ki-67 proteins, as potential biomarkers to select candidate patients for further studies of novel HCC treatment related to these targets.
Keyphrases
- copy number
- binding protein
- mitochondrial dna
- genome wide
- protein protein
- end stage renal disease
- cell proliferation
- ejection fraction
- label free
- dna methylation
- amino acid
- gene expression
- newly diagnosed
- neoadjuvant chemotherapy
- loop mediated isothermal amplification
- peritoneal dialysis
- small molecule
- locally advanced
- nucleic acid
- lymph node
- long non coding rna