Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate.

Meng-Ying WangDongjing LiuHolger SchwenderHong WangPing WangZhibo ZhouJing LiTao WuHongping ZhuTerri H Beaty

Published in: Oral diseases (2018)

While the single SNP association and the gene-environment interaction analysis of 14 CHRN genes yielded no signal, this study did demonstrate the importance of considering potential GxG interaction for exploring etiology of NSCL/P. This study suggests an important role for particular combinations of SNPs in CHRN genes in influencing risk to NSCL/P, which needs further study.

Keyphrases

genome wide
genome wide identification
gene expression
copy number
binding protein
human health