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Combined Effects of Tanshinone IIA and an Autophagy Inhibitor on the Apoptosis of Leukemia Cells via p53, Apoptosis-Related Proteins and Oxidative Stress Pathways.

Ying-Chyi SongCheng-Chieh KuoChuan-Teng LiuTsai-Chen WuYi-Ting KuoHung-Rong Yen
Published in: Integrative cancer therapies (2022)
The results suggest that TAIIA and autophagy inhibitors have combined effects on the apoptosis of leukemia cells, thus representing a novel and effective combination with the potential for application as a clinical therapy for AML.
Keyphrases
  • cell cycle arrest
  • induced apoptosis
  • endoplasmic reticulum stress
  • oxidative stress
  • cell death
  • pi k akt
  • acute myeloid leukemia
  • signaling pathway
  • bone marrow
  • dna damage
  • diabetic rats
  • acute lymphoblastic leukemia