HIV drug resistance in persons who inject drugs enrolled in an HIV prevention trial in Indonesia, Ukraine, and Vietnam: HPTN 074.
Philip J PalumboYinfeng ZhangJessica M FogelXu GuoWilliam ClarkeAutumn BreaudPaul RichardsonEstelle Piwowar-ManningStephen HartErica L HamiltonNgo T K HoaMariia LiulchukLatifah AnandariTran Viet HaKostyantyn DumchevZubairi DjoerbanIrving HoffmanBrett HanscomWilliam C MillerSusan H EshlemanPublished in: PloS one (2019)
In HPTN 074, many of the enrolled index participants had HIV drug resistance and more than half of those had multi-class resistance. Some newly-diagnosed participants had resistance, suggesting that they may have been infected with drug-resistant HIV strains. Behavioral and geographic factors were associated with baseline resistance. Baseline resistance was associated with reduced viral suppression during study follow-up. These findings indicate the need for enhanced HIV care in this high-risk population to achieve sustained viral suppression on ART.
Keyphrases
- antiretroviral therapy
- drug resistant
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- hepatitis c virus
- hiv aids
- newly diagnosed
- multidrug resistant
- men who have sex with men
- sars cov
- acinetobacter baumannii
- escherichia coli
- clinical trial
- south africa
- pseudomonas aeruginosa
- phase ii
- cystic fibrosis
- phase iii