HSP90 Mediates IFNγ-Induced Adaptive Resistance to Anti-PD-1 Immunotherapy.

Ke LiuJun HuangJiao LiuChangfeng LiGuido KroemerDaolin TangRui Kang

Published in: Cancer research (2022)

This study reveals an HSP90-centric, iron-modulated mechanism that confers immunosuppression, offering potential therapeutic targets for interfering with acquired resistance to the most prevalent anticancer immunotherapies.

Keyphrases

heat shock protein
heat shock
heat stress
high glucose
immune response
dendritic cells
endothelial cells
risk assessment