Heart Failure and Diabetes Mellitus: Dangerous Liaisons.
Hae-Young LeePublished in: International journal of heart failure (2022)
Patients with diabetes mellitus (DM) have a higher prevalence of heart failure (HF) than those without it. Approximately 40% of HF patients have DM, having poorer outcomes than those without DM. Myocardial ischemia caused by endothelial dysfunction, renal dysfunction, obesity, and impaired myocardial energetics is pathophysiology of DM-induced HF (DM-HF). Also, patients with HF show an increased risk for the onset of DM due to several mechanisms including insulin resistance. This review is focused on the epidemiology, pathogenic mechanism and treatment strategy of DM-HF.
Keyphrases
- glycemic control
- acute heart failure
- heart failure
- insulin resistance
- type diabetes
- left ventricular
- metabolic syndrome
- end stage renal disease
- weight loss
- adipose tissue
- oxidative stress
- risk factors
- high fat diet
- chronic kidney disease
- newly diagnosed
- prognostic factors
- atrial fibrillation
- high fat diet induced
- endothelial cells
- body mass index
- cardiac resynchronization therapy
- replacement therapy