Lynch Syndrome: From Multidisciplinary Management to Precision Prevention.
Arianna Dal BuonoAlberto PucciniGianluca FranchellucciMarco AiroldiMichela BartoliniPaolo Pietro BianchiArmando SantoroAlessandro RepiciCesare HassanPublished in: Cancers (2024)
Although robust diagnostic algorithms, including prompt testing of tumor tissue for MMR defects and referral for genetic counselling, currently exist for suspected LS in CRC patients, the indications for LS screening in cancer-free individuals still need to be refined and standardized. Investigation into additional genetic and non-genetic factors that may explain residual rates of interval cancers, even in properly screened populations, would allow for more tailored preventive strategies.
Keyphrases
- end stage renal disease
- genome wide
- chronic kidney disease
- machine learning
- newly diagnosed
- primary care
- peritoneal dialysis
- smoking cessation
- papillary thyroid
- prognostic factors
- deep learning
- pulmonary embolism
- case report
- patient reported outcomes
- squamous cell
- hiv testing
- human immunodeficiency virus
- men who have sex with men