Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXCR2.

Kawthar DhayniYuthiline ChabryLucie HénautCarine AvondoCedric BoudotHakim Ouled-HaddouEdith Bigot-CorbelGilles TouatiThierry CausHind MessaoudiJérémy BellienChristophe Tribouilloy David Messika-ZeitounKazem ZibaraSaïd KamelYoussef Bennis

Published in: Cardiovascular research (2023)

Overall, these results highlight, for the first time, a significant role for IL-8 in the progression of CAVD by promoting calcification via a CXCR2-- and MMP-12-dependent mechanism that leads to elastin degradation, and identify CXCR2 as a promising therapeutic target for the treatment of CAVD.

Keyphrases

aortic valve
cell migration
transcatheter aortic valve replacement
transcatheter aortic valve implantation
aortic valve replacement
aortic stenosis
chronic kidney disease
combination therapy
replacement therapy