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Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXCR2.

Kawthar DhayniYuthiline ChabryLucie HénautCarine AvondoCedric BoudotHakim Ouled-HaddouEdith Bigot-CorbelGilles TouatiThierry CausHind MessaoudiJérémy BellienChristophe TribouilloyDavid Messika-ZeitounKazem ZibaraSaïd KamelYoussef Bennis
Published in: Cardiovascular research (2023)
Overall, these results highlight, for the first time, a significant role for IL-8 in the progression of CAVD by promoting calcification via a CXCR2-- and MMP-12-dependent mechanism that leads to elastin degradation, and identify CXCR2 as a promising therapeutic target for the treatment of CAVD.
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