Impact of climate factors and climate-gene interaction on systemic lupus erythematosus patients' response to glucocorticoids therapy.

Tingyu ZhangQiaomei XieLinlin WangYuhua WangZiye YanZhen LiYing TengZhiwei XuYangfan ChenFa-Ming PanJinhui TaoJing CaiChunmei LiangHai-Feng PanHong SuJian ChengWenbiao HuYan-Feng Zou

Published in: Journal of clinical laboratory analysis (2023)

Our findings suggest that climate variability influences SLE patients' response to the therapy of GCs. Interactions between climate and TRAP1/GR gene polymorphisms were related to GCs efficacy. The results guide the individualized treatment of SLE patients.

Keyphrases

systemic lupus erythematosus
end stage renal disease
ejection fraction
newly diagnosed
climate change
chronic kidney disease
prognostic factors
stem cells
patient reported outcomes
patient reported
drug induced