Impact of climate factors and climate-gene interaction on systemic lupus erythematosus patients' response to glucocorticoids therapy.
Tingyu ZhangQiaomei XieLinlin WangYuhua WangZiye YanZhen LiYing TengZhiwei XuYangfan ChenFa-Ming PanJinhui TaoJing CaiChunmei LiangHai-Feng PanHong SuJian ChengWenbiao HuYan-Feng ZouPublished in: Journal of clinical laboratory analysis (2023)
Our findings suggest that climate variability influences SLE patients' response to the therapy of GCs. Interactions between climate and TRAP1/GR gene polymorphisms were related to GCs efficacy. The results guide the individualized treatment of SLE patients.