Stakeholders' views and perspectives on treatments of visceral leishmaniasis and their outcomes in HIV-coinfected patients in East Africa and South-East Asia: A mixed methods study.
Joanne KhabsaSaurabh JainAmena El-HarakehCynthia RizkallahDhruv K PandeyNigus ManayeGladys Honein-AbouHaidarChristine HalleuxDaniel Argaw DagneElie A AklPublished in: PLoS neglected tropical diseases (2022)
Mortality and non-serious adverse events were rated as "critical" by respectively the highest (61%) and lowest percentages (47%) of survey participants. Participants viewed clinical cure as essential for patients to regain productivity. Non-patient stakeholders emphasized the importance of "sustained" clinical cure. For most survey participants, combination therapy, compared with monotherapy, would increase health equity (40%), and be more acceptable (79%) and feasible (57%). Interviews revealed that combination therapy was more feasible and acceptable than monotherapy when associated with a shorter duration of hospitalization. The findings of the interviews provided insight into those of the survey. When choosing between alternative options, providers should consider the outcomes that matter to patients as well as the impact on equity, feasibility, and acceptability of the options.
Keyphrases
- combination therapy
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- peritoneal dialysis
- prognostic factors
- clinical trial
- type diabetes
- public health
- metabolic syndrome
- coronary artery disease
- weight loss
- mental health
- adipose tissue
- hiv positive
- risk factors
- cardiovascular events
- men who have sex with men
- hiv aids
- gastric bypass
- patient reported