MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis.
Sirio CocozzaGiuseppe PontilloRoberta LanzilloCamilla RussoMaria PetraccaMartina Di StasiChiara PaolellaElena Augusta VolaChiara CriscuoloMarcello MocciaAnna LambertiSerena MontiVincenzo Brescia MorraAndrea ElefanteGiuseppe PalmaEnrico TedeschiArturo BrunettiPublished in: Neuroradiology (2019)
MS patients with DN hyperintensity show similar EDSS changes compared to subjects without DN high-signal intensity. Furthermore, mean DN-R1 values of patients with significant clinical worsening were comparable to those of stable subjects and were unrelated to clinical disability. Taken together, these findings suggest that gadolinium retention in the brain of MS patients does not affect their clinical worsening, expressed by the EDSS change.
Keyphrases
- multiple sclerosis
- white matter
- mass spectrometry
- contrast enhanced
- end stage renal disease
- magnetic resonance imaging
- chronic kidney disease
- newly diagnosed
- ms ms
- ejection fraction
- diffusion weighted imaging
- computed tomography
- high intensity
- resting state
- blood brain barrier
- functional connectivity
- cerebral ischemia