Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages.

Yang WangRongjun WanChengping Hu

Published in: Molecular medicine (Cambridge, Mass.) (2023)

Our results demonstrate leptin/obR signaling plays an important role in the pathogenesis of obesity-related neutrophilic airway inflammation in females by promoting M1 macrophage polarization.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
type diabetes
high fat diet induced
weight gain
oxidative stress
adipose tissue
body mass index
physical activity