Human regular U-500 insulin via continuous subcutaneous insulin infusion versus multiple daily injections in adults with type 2 diabetes: The VIVID study.
George GrunbergerAnuj BhargavaTrang LyHoward ZisserLiza L IlagJames MaloneLudi FanShuyu ZhangJennal JohnsonPublished in: Diabetes, obesity & metabolism (2020)
In type 2 diabetes requiring high doses of insulin, both methods of U-500R delivery lowered HbA1c. However, the CSII group attained greater HbA1c reduction with significantly less insulin. Individualized dose titration will be important to balance glycaemic control with hypoglycaemia risk.