Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.
Dongqin WuNana YuYang GaoRui XiongLuping LiuHuiyang LeiSen JinJiale LiuYingzhou LiuJiazhao XieEnjie LiuQiuzhi ZhouYanchao LiuShihong LiLinyu WeiJingru LvHuilin YuWenbo ZengQiang ZhouFuqiang XuMin-Hua LuoYao ZhangYing YangJian-Zhi WangPublished in: Molecular neurodegeneration (2023)
Our study not only reveals the vulnerability of a novel MS-CA1 cholinergic circuit to AD-like tau accumulation but also provides a rhythm- and time window-dependent strategy to target the MS-CA1 cholinergic circuit, thereby rescuing tau-induced spatial cognitive functions.