Solid SiO 2 -Sealed Mesoporous Silica for Synergistically Combined Use of Inorganic and Organic Filters to Achieve Safe and Effective Skin Protection from All-Band UV Radiation.

To effectively shield the full band of ultraviolet (UV) radiation and provide desirable protection, the combination of inorganic and organic filters was often used to protect human skin from the serious harm of UV exposure. However, the incompatibility of different filters and their mutual negative effect limit the production of multifilter sunscreen. In addition, the hazard of reactive oxygen species (ROS) produced by inorganic filters after UV exposure and the skin permeability of organic filters remain unresolved problems. In this study, titanium dioxide (TiO 2 ) and diethylamino hydroxybenzoyl hexyl benzoate (DHHB), two kinds of common filters with complementary UV shielding range, were first encapsulated into large mesoporous silica nanoparticles (MSN, ∼300 nm) to obtain MSN-TiO 2 and MSN-DHHB. Also, a SiO 2 coating was then made to seal and stabilize the MSN-TiO 2 and MSN-DHHB. The structure, UV screen function, and safety of the SiO 2 -coated filters, MSN-TiO 2 @SiO 2 and MSN-DHHB@SiO 2 , were evaluated. The good mechanical stability exhibited by the solid SiO 2 layer prevented the release and skin penetration of the sealed DHHB and the photocatalysis of TiO 2 . Furthermore, the combination of MSN-TiO 2 @SiO 2 and MSN-DHHB@SiO 2 in sunscreen cream showed excellent UV shielding performance on covering the whole UV radiation range without mutual interference. Therefore, coating SiO 2 over MSN is a feasible strategy for entrapping various filters to improve their photostability, preventing skin penetration and ROS generation, and enhancing their compatibility with different sunscreen formulations.