Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells.
Giulia CorradiBarbara BassaniFrancesco LanzaSabina SangalettiJayakumar VadakekolathuMaria Chiara FontanaMartina PazzagliaAlessandro GulinoClaudio TripodoGianluca CristianoLorenza BandiniEmanuela OttavianiDarina OcadlikovaMilena PiccioliGiovanni MartinelliMario Paolo ColomboSergio RutellaMichele CavoMarilena CiciarelloAntonio CurtiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
IFNγ release by AML cells induces an immune-regulatory program in MSCs and remodels BM immunologic landscape toward Treg induction, contributing to an immunotolerant microenvironment. See related commentary by Ferrell and Kordasti, p. 2986.
Keyphrases
- regulatory t cells
- acute myeloid leukemia
- induced apoptosis
- dendritic cells
- bone marrow
- cell cycle arrest
- mesenchymal stem cells
- stem cells
- immune response
- allogeneic hematopoietic stem cell transplantation
- endoplasmic reticulum stress
- transcription factor
- quality improvement
- acute lymphoblastic leukemia
- umbilical cord
- drug induced