Epithelial disruptions, but not immune cell invasion, induced secretory dysfunction following innate immune activation in a novel model of acute salivary gland injury.

Abeer K Shaalan Guy Howard Carpenter Gordon B Proctor

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)

In this study, we developed a novel injury model of the SGs, featuring acute secretory dysfunction and immediate structural disruptions. Our results ruled out the injurious role of aggressively infiltrating inflammatory cells.

Keyphrases

liver failure
innate immune
drug induced
oxidative stress
respiratory failure
induced apoptosis
aortic dissection
diabetic rats
cell cycle arrest
hepatitis b virus
extracorporeal membrane oxygenation
signaling pathway
mechanical ventilation
stress induced