Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India.

Alen Joe JosephBaehat DhakalSathvik Reddy ErlaYogendra SinghLata SinghAshish D UpadhyayNarendra Kumar BagriRakesh LodhaS K Kabra

Published in: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (2024)

MSAs/MAAs were identified in 81% of children with JDM in our study, which is higher than most other studies. The most frequently observed antibodies displayed a pattern consistent with other studies. Anti-TIF1γ was associated with a younger age at onset and disease flares even after attaining a complete clinical response. Anti-NXP2 had higher odds of severe muscular weakness. These observations suggest consistency in certain phenotypic associations observed across geographic boundaries.

Keyphrases

case control
young adults
systemic lupus erythematosus
risk factors
interstitial lung disease
early onset
disease activity
resistance training