Anti-CD20 Disrupts Meningeal B-Cell Aggregates in a Model of Secondary Progressive Multiple Sclerosis.

Jay RoodselaarYifan ZhouDavid LeppertAnja E HauserEduard UrichDaniel C Anthony

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

These results indicate that anti-CD20 may be an effective therapy for SPMS with B-cell aggregates and that the elimination of CD20+ B cells alone is sufficient to cause disruption of aggregates in the brain.

Keyphrases

multiple sclerosis
white matter
nk cells
resting state
brain injury
functional connectivity
cerebral ischemia
subarachnoid hemorrhage