Hematologic safety of palbociclib in combination with endocrine therapy in patients with benign ethnic neutropenia and advanced breast cancer.
Filipa C LynceMatthew J BlackburnRebecca ZhuoChristopher GallagherOlwen M HahnMaysa Abu-KhalafMahsa MohebtashTianmin WuPaula R PohlmannAsma DilawariShruti R TiwariAmi ChitaliaRobert WarrenMing TanAyesha N Shajahan-HaqClaudine IsaacsPublished in: Cancer (2021)
These findings suggest that palbociclib is well tolerated in African American women with HR-positive/HER2-negative ABC. Duffy null status may affect the incidence of grade 3 neutropenia, dose intensity, and possibly clinical benefit.