Trained Immunity Based-Vaccines as a Prophylactic Strategy in Common Variable Immunodeficiency. A Proof of Concept Study.
Kissy Guevara-HoyerPaula Saz-LealCarmen M Diez-RiveroJuliana Ochoa-GrullónMiguel Fernández-ArqueroRebeca Pérez de DiegoSilvia Sánchez-RamónPublished in: Biomedicines (2020)
The sublingual administration of the TIbV MV130 significantly reduced the rate of respiratory infections, antibiotic use and unscheduled visits, while increasing specific IgA responses in CVID patients. Additionally, the CVID population felt that their QoL was improved, and a decrease in expenses derived from health care was predicted.