Epigenetic regulation of TLR2-mediated periapical inflammation.

Alejandra Fernández P VelosoJ AstorgaC RodríguezV A TorresM ValdésM GarridoP J Gebicke-HaerterMarcela Hernandez

Published in: International endodontic journal (2020)

TLR2 gene promoter hypomethylation was linked to transcriptional activity of pro-inflammatory cytokines and angiogenic markers in exacerbated periapical inflammation. Moreover, unmethylated single sites in close proximity to NFκB binding were involved in active transcription of IL-23, IL-10 and CDH5.

Keyphrases

oxidative stress
transcription factor
toll like receptor
inflammatory response
nuclear factor
immune response
gene expression
signaling pathway
dna methylation
lps induced
cone beam computed tomography
copy number
dna binding
genome wide
genome wide identification
pi k akt
anti inflammatory