Novel Anaplastic Thyroid Cancer PDXs and Cell Lines: Expanding Preclinical Models of Genetic Diversity.

Anastasios ManiakasYing C HendersonHu HeiShaohua PengYunyun ChenYujie JiangShuangxi JiMaria CardenasYulun ChiuDiana BellMichelle D WilliamsMarie-Claude HofmannSteve E SchererDavid A WheelerNaifa L BusaidyRamona DaduJennifer R WangMaria E CabanillasMark ZafereoFaye M JohnsonStephen Y Lai

Published in: The Journal of clinical endocrinology and metabolism (2021)

We have developed and characterized 6 novel ATC PDX models with 4 matching cell lines. Each PDX model harbors a distinct genetic profile, making them excellent tools for preclinical therapeutic trials.

Keyphrases

genetic diversity
cell therapy
genome wide
copy number
mesenchymal stem cells
dna methylation
bone marrow