Refining immunotherapeutic approaches to high-risk neuroblastoma based on tumor genomic profiles.

Published in: Molecular oncology (2020)

In this issue, Coronado et al. attempt to improve our understanding of the factors affecting the response to immunotherapy in a large subset of high-risk neuroblastoma with hemizygous deletion of chromosome 11q. By using several computational approaches, the authors study potential transcriptional and post-transcriptional pathways that may affect the response to immunotherapy and further be leveraged therapeutically in a biomarker-directed fashion.

Keyphrases

gene expression
transcription factor
copy number
dna methylation
oxidative stress
climate change
genome wide