An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities.

John H Postlethwait Dylan R Farnsworth Adam C Miller

Published in: bioRxiv : the preprint server for biology (2020)

Genomic analyses identify zebrafish orthologs of the Renin-Angiotensin-Aldosterone System that contribute to COVID-19 comorbidities and single-cell transcriptomics show that they act in a specialized intestinal cell type.

Keyphrases

sars cov
angiotensin converting enzyme
angiotensin ii
single cell
coronavirus disease
respiratory syndrome coronavirus
rna seq
palliative care
high throughput
copy number
gene expression
dna methylation