New insights into regulation of αIIbβ3 integrin signaling by filamin A.

Lamia LamraniFrédéric AdamChristelle SoukaseumCecile V DenisHana RaslovaJean-Philippe RosaMarijke Bryckaert

Published in: Research and practice in thrombosis and haemostasis (2022)

We conclude that FLNa negatively controls αIIbβ3 activation by regulating actin polymerization and restraining activation of Rac, as well as outside-in signaling by repressing Rho.

Keyphrases

cell migration
protein kinase
cell adhesion