A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study.
Thomas BreslinJason PainoMarie WegnerElette E M EngelsStefan FiedlerHelen ForresterHannes RennauJohn BustilloMatthew CameronDaniel HäusermannChristopher HallDieter KrauseGuido HildebrandtMichael LerchElisabeth SchültkePublished in: Biomimetics (Basel, Switzerland) (2023)
The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.
Keyphrases
- monte carlo
- image quality
- dual energy
- early stage
- radiation induced
- locally advanced
- computed tomography
- high dose
- radiation therapy
- clinical trial
- end stage renal disease
- newly diagnosed
- ejection fraction
- endothelial cells
- low dose
- machine learning
- prognostic factors
- contrast enhanced
- electronic health record
- peritoneal dialysis
- deep learning
- positron emission tomography
- molecular dynamics
- big data
- patient reported outcomes
- phase ii
- artificial intelligence
- mass spectrometry
- phase iii
- pet ct
- liquid chromatography