The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+ tumour-infiltrating lymphocytes.
Diego Salas-BenitoEnrique CondeIbon Tamayo-UriaUxua MancheñoEdurne ElizaldeDavid Garcia-RosJosé Manuel AramendíaJuan C MuruzabalJulia AlcaideFrancisco Guillen-GrimaJose A MinguezJose Amores-TiradoAntonio Gonzalez-MartinPablo SarobeJuan J LasarteMariano Ponz-SarviséCarlos E De AndreaSandra Hervás-StubbsPublished in: British journal of cancer (2021)
We have demonstrated that PD-1 identifies ovarian tumour-specific CD8 TILs and has uncovered predictive factors that identify OC patients who are likely to render tumour-specific cells from PD-1+ TILs.