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Tumor-Specific CD8 + T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes.

Elizabeth M ZawidzkaLuca BiavatiAmy ThomasClaudio ZanettiniLuigi MarchionniRobert LeoneIvan Borrello
Published in: bioRxiv : the preprint server for biology (2023)
The BM could serve as an alternative source of cells for adoptive cellular therapy for solid tumors.
Keyphrases
  • bone marrow
  • induced apoptosis
  • mesenchymal stem cells
  • cell therapy
  • cell cycle arrest
  • peripheral blood
  • signaling pathway
  • cell proliferation