Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy.
Anne CornelissenNeel V GadhokeKathleen A RyanChani J HodonskyRebecca MitchellNathan A BihlmeyerThuyVy DuongZhifen ChenArmelle DikongueAtsushi SakamotoYu SatoRika KawakamiMasayuki MoriKenji KawaiRaquel FernandezSaikat Kumar B GhoshRyan BraumannBiniyam AbebeRobert KutysMatthew KutynaMaria E RomeroFrank D KolodgieClint T MillerCharles C HongMegan L GroveJennifer A BrodyNona SotoodehniaDan E ArkingHeribert SchunkertBraxton D MitchellLiang GuoRenu VirmaniAloke V FinnPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
This is the first autopsy study investigating associations between PRS and atherosclerosis severity at the histopathologic level in subjects with sudden death. Our pathological analysis suggests PRS correlates with plaque burden and features of advanced atherosclerosis and may be useful as a method for CAD risk stratification, especially in younger subjects.