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Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy.
Mengzhen Wang
Kaixian Wang
Xiaohan Liu
Mingwan Shi
Huiwen Zhang
Xia Zhang
Ruyue Wei
Na Li
Wei Pan
Bo Tang
Published in:
Chemical communications (Cambridge, England) (2023)
We designed and synthesized tumor-targeted nanoflowers to inhibit glutamine metabolism and amplify oxidative stress, which could synergistically suppress tumor growth.
Keyphrases
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oxidative stress
cancer therapy
dna damage
ischemia reperfusion injury
diabetic rats
induced apoptosis
drug delivery
mesenchymal stem cells
endoplasmic reticulum stress
heat stress