White matter alterations and their associations with biomarkers and behavior in subjective cognitive decline individuals: a fixel-based analysis.

Yi-Chia WeiYi-Chia KungChing-Po LinChih-Ken ChenChemin LinRung-Yu TsengYao-Liang ChenWen-Yi HuangPin-Yuan ChenShin-Tai ChongYu-Chiau ShyuWei-Chou ChangChun-Hung Yeh

Published in: Behavioral and brain functions : BBF (2024)

Based on FBA, our investigation suggests white matter structural alterations in SCD. The enlargement of SLFII's fiber cross-section is linked to plasma Aβ42 and neuropsychiatric symptoms, which suggests potential early axonal dystrophy associated with Alzheimer's pathology in SCD. The splenium of the corpus callosum is also a critical region of axonal degeneration and cognitive alteration for SCD.

Keyphrases

cognitive decline
white matter
mild cognitive impairment
multiple sclerosis
spinal cord injury
sleep quality
early onset
optic nerve
depressive symptoms