Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function.

Shawn J MachaBalakrishna Koneru Trevor A Burrow Charles Zhu Dzmitry SavitskiRakhshanda L RahmanCatherine A RonaghanJonas NanceKristyn McCoyCody Eslinger C Patrick Reynolds

Published in: Cancer research (2022)

This work demonstrates that constitutive activation of ATM in chemotherapy-refractory ALT cancer cells renders them hypersensitive to reactivation of p53 function by APR-246, indicating a potential strategy to overcome therapeutic resistance.

Keyphrases

papillary thyroid
climate change
dna damage
dna repair
locally advanced
squamous cell carcinoma
radiation therapy
risk assessment
oxidative stress
human health
rectal cancer
lymph node metastasis