Apheresis for chimeric antigen receptor T-cell production in adult lymphoma patients.

Dennis Christoph HarrerMartin HeidenreichMatthias Alexander FanteViktoria MüllerViola HaehnelRobert OffnerRalph BurkhardtWolfgang HerrMatthias EdingerDaniel WolffSimone ThomasAndreas Brosig

Published in: Transfusion (2022)

Lymphapheresis with the Spectra Optia cMNC program provided a sufficient quantity of CD3-positive lymphocytes for CAR T-cell manufacturing for the majority of patients despite their heavy pretreatment and advanced age. Moreover, we are the first to advocate early pre-emptive lymphocyte collection in DLBCL-NOS patients intended to undergo treatment with Tisagenlecleucel.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
nitric oxide
density functional theory