Mismatch Repair-Proficient Colorectal Cancer: Finding the Right TiME to Respond.

Jason A WillisMichael James Overman Eduardo Vilar

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

New approaches are required for addressing the important and unmet need to expand the benefits of checkpoint blockade to patients with mismatch repair proficient colorectal cancer. Systematic profiling of the tumor immune microenvironment provides insights into potential mechanisms of resistance, predictive biomarkers, and novel combinatorial strategies for overcoming resistance.See related article by Llosa et al., p. 5250.

Keyphrases

stem cells
cell cycle
single cell
risk assessment
cell proliferation