A Real-World Nationwide Study on COVID-19 Trend in Italy during the Autumn-Winter Season of 2020 (before Mass Vaccination) and 2021 (after Mass Vaccination) Integrated with a Retrospective Analysis of the Mortality Burden per Year.
Luca RoncatiCarlo GaleazziGiulia BartolacelliStefania CaramaschiPublished in: Microorganisms (2024)
COVID-19 is a potential life-threatening disease mainly in older adults, as they are the most vulnerable due to inherent immunosenescence and inflammaging. Extensive vaccination in this segment of population with up-to-date vaccines is the means to reduce deaths, hospitalizations, and ICU pressure in the public interest. In the event of future threats, a new mass vaccination campaign should not be implemented without taking into account the individual age; it should primarily be aimed at people over 60 and at patients of any age with immune deficits, and secondly at people over 50. COVID-19 vaccination shows a favorable benefit-risk ratio in older adults, while the balance steps down under the age of 40; this younger segment of the population should be therefore exempt from any mandatory vaccination.
Keyphrases
- coronavirus disease
- sars cov
- physical activity
- healthcare
- traumatic brain injury
- end stage renal disease
- ejection fraction
- chronic kidney disease
- type diabetes
- risk assessment
- cardiovascular events
- cardiovascular disease
- coronary artery disease
- human health
- patient reported outcomes
- extracorporeal membrane oxygenation
- adverse drug
- electronic health record