Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy.

Collagen fiber density was positively associated with local, but not global, mammographic density, suggesting that collagen microarchitecture may not translate into macroscopic mammographic features. However, collagen fiber features may be markers of cancer risk and/or progression among women referred for biopsy based on abnormal breast imaging.