Mismatch Repair system protein deficiency as a resistance factor for locally advanced rectal adenocarcinoma patients receiving neoadjuvant chemo-radiotherapy.

Andrea PrettaPina ZiranuRiccardo GiampieriGiovanna PinnaGiovanni RandonClelia DonisiAlberto RavarinoFrancesco LoiGiulia DeiasEnrico PalmasGianluca PrettaFederica MoranoFrancesca SemonellaStefano MarianiMaria Assunta DeiddaValeria PuscedduMarco PuzzoniEleonora LaiCinzia SolinasAngelo RestivoLuigi ZorcoloRaffaele BarbaraRossana BerardiGavino FaaFilippo Pietrantonio Mario Scartozzi

Published in: British journal of cancer (2023)

Our results indicated an association between dMMR and poor response to preoperative chemoradiotherapy and they represent a hypothesis-generating data for new neoadjuvant strategies.

Keyphrases

locally advanced
rectal cancer
squamous cell carcinoma
radiation therapy
electronic health record
patients undergoing
big data
photodynamic therapy
binding protein
replacement therapy
small molecule
deep learning